This book was developed to provide a comprehensive overview of the clinical and basic science aspects of Multiple Sclerosis. It is designed to be of practical use to clinical neurologists, as well as other health care professionals who treat persons withMS. It addresses all of the major issues that may occur in the management of persons with MS. The reader is provided with the latest information on the science of MS, including immunology, genetics, epidemiology and pathology, as well as a summary of thenewest directions in basic science research. Guidelines for diagnosis and appropriate use of diagnostic modalities are presented. All clinical aspects of MS are discussed, including extensive information on aspects that may be more challenging for the neurologist to manage, such as sleep disorders and pain. Disease modifying therapies, including those that are FDA approved, as well as off label and experimental therapies are discussed. Finally, there are chapters on employment and legal issues, as well as an overview of clinical trials and clinical trial outcome measures, which are helpful in reviewing the scientific literature in these areas. Contains extensive chapters on sleep disorders, pain, and cognitive problems that are not found in most MS books; Includes chapters on employment issues and legal planning which gives clinicians greater insight on challenges the MS patient faces; Emphasizes practical clinical information that can be used for patient care -- From publisher.