From naughty children to rebellious teenagers and mixed-up twenty- and thirty-somethings, Rosie and Alex have stuck by each other through thick and thin, even when Alex moved across the Atlantic to Boston and Rosie fell pregnant as a teenager.
Alex supports Rosie through one of the most difficult times of her life - a time when she should be out partying and going to university but is instead changing nappies and coping with a screaming baby. In return, Rosie is there for Alex when he struggles through his medical internship and copes with a messy divorce. Throughout the ups and downs of each other's lives, they have remained a constant, a shoulder to cry on, someone to laugh and share their innermost feelings with.
But can their friendship survive the years and the miles and, more critically, when they each marry someone else? Were they meant to be more than just good friends all along? Misunderstandings, circumstances and sheer bad luck have meant that they have never been able to see whether their friendship runs deeper - but now that nothing stands in their way, will they gamble everything for true love?