Chris Michaels and Abbie Colman should never have met let alone fallen in love. As the only child of South Carolina's most senior senator, Abbie's father had wanted better for her than Chris, who grew up in a trailer park next to the St Mary's river. Abbie and Chris had married quickly and secretly, returning to face her parents' objections that haven't faded even after over fourteen years of marriage.
But now Abbie and Chris are coming to the end of the road. Diagnosed with breast cancer four years before, Abbie's case is now terminal and they've run out of options. Rather than letting Abbie spend her final days in a cold, sterile hospital room, Chris packs their bags and steals away with her in the middle of the night.
They carry with them Abbie's 'wish list' - ten things she wants to do before she dies. The wishes are simple, normal; because after four years of non-stop invasive medical treatments, 'normal' is a fleeting memory. Along with taking a final trip with Chris on the river that holds so many memories for them both, Abbie wants to dance with her husband, drink wine on a beach, laugh until it hurts. But as they head for river's end, racing against weather and time, Abbie's father, the press and the police are determined to find them and bring Abbie home.