Audrey Niffenegger was born in 1963 in the idyllic hamlet of South Haven, Michigan. Her family moved to Evanston, Illinois when she was little; she has lived in or near Chicago for most of her life.
Audrey trained as a visual artist at the School of the Art Institute of Chicago, and received her MFA from Northwestern University's Department of Art Theory and Practice in 1991. She has exhibited her artist's books, prints, paintings, drawings and comics at Printworks Gallery in Chicago since 1987.
Her first books were printed and bound by hand in editions of ten. Two of these have since been commercially published by Harry N. Abrams: The Adventuress and The Three Incestuous Sisters.